Sickle Cell CRISPR: HBB Loss of Allele Mechanisms
Molecular pathway analysis of why Cas9 editing at the HBB sickle cell locus triggers Loss of Allele through DNA repair failure, PCNA dynamics, and centromeric HBG deletion.
May 21, 2026
Research Hub
Explore citation-grounded hypotheses, methods, and pathways built from the literature, ready for your next experiment. Each brief opens as a live BioSkepsis research conversation you can continue inside the app.
Curated insights into disease-relevant molecular pathways and gene networks. Each brief is backed by a live BioSkepsis research conversation. Open it in the app to trace mechanisms, branch into specific targets, or compare pathways across conditions.
Targeted therapy resistance in KRAS- and EGFR-mutant NSCLC: on-target mutations, bypass signaling, and lineage plasticity
How on-target mutations, bypass signaling via MET and ERBB3, lineage plasticity, and APOBEC3B-driven mutagenesis interact to drive inevitable resistance in KRAS- and EGFR-mutant lung cancer.
May 20, 2026
MASLD to MASH-HCC: Molecular Signaling Networks and the Immunologically Cold Tumor Microenvironment
Molecular signaling networks driving MASLD steatosis through MASH fibrosis to hepatocellular carcinoma, and how converging lipotoxic, fibrogenic, and immune axes create the immunologically cold MASH-HCC TME.
May 20, 2026
Submit a Topic for Biomedical AI Synthesis
Can't find the molecular pathway or research frontier you want? Submit a request and suggest how we can expand our library of peer-reviewed insights and mechanistic hypotheses with evidence-grounded hypotheses.