Does Intermittent Fasting Rewire the Gut-Brain Appetite Axis Through Microbial Metabolites?
Three testable hypotheses on how intermittent fasting reshapes the gut-brain axis via Lactobacillus-derived ILA and microbial acetate to suppress appetite.
Hypothesis Briefs · The Hypothesis Register
Hypothesis Briefs
Evidence-grounded, testable hypotheses on emerging biomedical topics. Each brief is backed by a live BioSkepsis research conversation. Open it in the app to challenge the hypothesis, expand the evidence base, or adapt it for your own grants and protocols.
Featured brief · 12/06/2026
Are Peptideins the Missing Regulators of Cancer Cell Viability? Three Testable Hypotheses from the Dark Proteome
Three testable hypotheses on how non-coding microproteins (peptideins) regulate cancer survival via splicing, scaffolding, and degradation pathways.
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Can Reversing Thymic Involution Extend Longevity, Reduce Cardiovascular Mortality, and Rescue Cancer Immunotherapy?
Three testable hypotheses on reversing adult thymic involution to restore TCR diversity, cut cardiovascular mortality, and rescue checkpoint blockade.
Can GLP-1 Receptor Agonists Suppress Mammary Tumor Initiation Through Niche Disruption and Immune Restoration?
Three testable hypotheses on how semaglutide may suppress mammary tumor initiation via CXCL12/CXCR4 niche disruption and cAMP/PKA-mediated immune restoration.
Do Senescence-Associated Glycosidases Drive IgG Glycan Aging?
Three testable hypotheses on how senescence-associated glycosidases drive IgG degalactosylation, accelerate inflammaging, and reset the glycan clock.
Does Gcn5-Mediated Epigenetic Regulation Gate Efflux, Membrane Remodeling, and Polyene Resistance in Candida auris?
Three testable hypotheses on how Gcn5-mediated H3K14 acetylation governs efflux, sphingolipid remodeling, and polyene resistance in Candida auris clades.
Can Dual GLP-1/GIP Agonism Stabilize Upper Airway Patency and Coronary Perfusion Through eNOS Signaling?
Three testable hypotheses on how tirzepatide's dual GIP/GLP-1 agonism may stabilize upper airway tone and coronary perfusion via Akt-AMPK-eNOS signaling.
Do RNA Chemical Modifications Encode a Second Layer of Gene Regulation?
Do RNA chemical modifications such as m6A, m5C, pseudouridine, and A-to-I editing form a higher-order regulatory system that encodes transcript fate, ribosome specialization, and chromatin–RNA feedback loops? Explore three testable hypotheses on epitranscriptomic combinatorial codes, m6A–chromatin crosstalk in cancer apoptosis resistance, and rRNA modification-driven ribosome heterogeneity shaping stress-responsive translation.
Does Nuclear Lamina Repair Enable Epigenetic Clock Reset in Partial Reprogramming?
Does restoration of nuclear envelope integrity and Lamin-Associated Domain (LAD) tethering during OSK-mediated partial reprogramming enable recruitment of TET1/2 to age-associated CpG sites, or is pioneer-factor-driven chromatin opening strictly required for epigenetic clock reversal? Explore mechanistic causality between 3D genome architecture repair, chromatin accessibility, and DNA methylation reset in cellular rejuvenation.
AlphaFold 3 for Ternary Complex Prediction
Can AlphaFold 3 accurately predict ternary complex geometries for molecular glues and targeted protein degradation? Explore current evidence, structural limitations, benchmarking studies, and implications for drug discovery.