Research Hub
Explore citation-grounded hypotheses, methods, and pathways built from the literature, ready for your next experiment. Each brief opens as a live BioSkepsis research conversation you can continue inside the app.
Hypothesis Briefs
The Hypothesis Register
Evidence-grounded, testable hypotheses on emerging biomedical topics. Each brief is backed by a live BioSkepsis research conversation. Open it in the app to challenge the hypothesis, expand the evidence base, or adapt it for your own grants and protocols.
Are Peptideins the Missing Regulators of Cancer Cell Viability? Three Testable Hypotheses from the Dark Proteome
Three testable hypotheses on how non-coding microproteins (peptideins) regulate cancer survival via splicing, scaffolding, and degradation pathways.
Read briefDoes Intermittent Fasting Rewire the Gut-Brain Appetite Axis Through Microbial Metabolites?
Three testable hypotheses on how intermittent fasting reshapes the gut-brain axis via Lactobacillus-derived ILA and microbial acetate to suppress appetite.
Read briefCan Reversing Thymic Involution Extend Longevity, Reduce Cardiovascular Mortality, and Rescue Cancer Immunotherapy?
Three testable hypotheses on reversing adult thymic involution to restore TCR diversity, cut cardiovascular mortality, and rescue checkpoint blockade.
Read briefMethod Briefs
The Method Register
Advanced experimental strategies and analytical frameworks. Each brief is backed by a live BioSkepsis research conversation. Open it in the app to drill into specific protocols, compare techniques, or adapt the methodology to your own dataset.
Whole-Body Imaging for Adoptive Cell Therapy Tracking: PET, MRI, Bioluminescence, and Fluorescence Compared
PET, MRI, BLI, and fluorescence imaging compared for tracking adoptive cell therapies in vivo. Resolution, sensitivity, and clinical validation reviewed.
Read briefCRISPR Base Editing and Prime Editing Protocols for Engineering Herbicide-Tolerant Staple Crops
Protocols for CRISPR base editing and prime editing in staple crops: guide RNA design, RNP delivery, off-target profiling, and field trial validation standards.
Read briefDeep Learning Architectures for Thymic Tissue Segmentation and Risk Scoring from Routine CT Scans
How nnU-Net, VGG16-MLP-Mixer, and radiomics-DL fusion models segment thymic tissue from routine CT scans and predict thymoma risk across multi-center cohorts.
Read briefPathway Briefs
The Pathway Register
Curated insights into disease-relevant molecular pathways and gene networks. Each brief is backed by a live BioSkepsis research conversation. Open it in the app to trace mechanisms, branch into specific targets, or compare pathways across conditions.
Osteoarthritis Cartilage Loss: 15-PGDH, PGE2 Metabolic Drainage, and Chondrocyte Phenotypic Respecification
How 15-PGDH accumulation drains PGE2 from aging cartilage, drives chondrocyte hypertrophy, and how its inhibition restores hyaline cartilage synthesis.
Read briefMicroplastics Disrupt the Oceanic Biological Carbon Pump: From Zooplankton Fecal Pellets to Radiocarbon Aliasing
Microplastics reduce fecal pellet sinking by 34%, alias radiocarbon dating by 4,000 years, and replace biogenic carbon with synthetic polymer at ocean depth.
Read briefOleic Acid vs Linoleic Acid in Pancreatic Cancer: Divergent Lipid Signaling from SREBP1-SCD1 to Ferroptosis
Oleic acid drives PDAC stemness and ferroptosis resistance via SCD1. Linoleic acid induces ferroptosis through lipid peroxidation and RIP3/MLKL necroptosis.
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