Do Senescence-Associated Glycosidases Drive IgG Glycan Aging?
Three testable hypotheses on how senescence-associated glycosidases drive IgG degalactosylation, accelerate inflammaging, and reset the glycan clock.
May 25, 2026
Research Hub
Explore citation-grounded hypotheses, methods, and pathways built from the literature, ready for your next experiment. Each brief opens as a live BioSkepsis research conversation you can continue inside the app.
Evidence-grounded, testable hypotheses on emerging biomedical topics. Each brief is backed by a live BioSkepsis research conversation. Open it in the app to challenge the hypothesis, expand the evidence base, or adapt it for your own grants and protocols.
Does Gcn5-Mediated Epigenetic Regulation Gate Efflux, Membrane Remodeling, and Polyene Resistance in Candida auris?
Three testable hypotheses on how Gcn5-mediated H3K14 acetylation governs efflux, sphingolipid remodeling, and polyene resistance in Candida auris clades.
May 25, 2026
Can Dual GLP-1/GIP Agonism Stabilize Upper Airway Patency and Coronary Perfusion Through eNOS Signaling?
Three testable hypotheses on how tirzepatide's dual GIP/GLP-1 agonism may stabilize upper airway tone and coronary perfusion via Akt-AMPK-eNOS signaling.
May 25, 2026
Do RNA Chemical Modifications Encode a Second Layer of Gene Regulation?
Do RNA chemical modifications such as m6A, m5C, pseudouridine, and A-to-I editing form a higher-order regulatory system that encodes transcript fate, ribosome specialization, and chromatin–RNA feedback loops? Explore three testable hypothes…
May 20, 2026
Does Nuclear Lamina Repair Enable Epigenetic Clock Reset in Partial Reprogramming?
Does restoration of nuclear envelope integrity and Lamin-Associated Domain (LAD) tethering during OSK-mediated partial reprogramming enable recruitment of TET1/2 to age-associated CpG sites, or is pioneer-factor-driven chromatin opening str…
May 20, 2026
AlphaFold 3 for Ternary Complex Prediction
Can AlphaFold 3 accurately predict ternary complex geometries for molecular glues and targeted protein degradation? Explore current evidence, structural limitations, benchmarking studies, and implications for drug discovery.
May 20, 2026
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